The ability to quantify and evaluate cities is a tremendous first step in determining future suitability of business operations in any site selection process. The Explore 2017 International Cities Business Index identifies the merits of key regional cities of commerce and establishes empirical reasoning towards leveraging the benefits of location in the global economy. The ExPLoRE report series is defined by site selection methodology, the cornerstone of which is thorough Examination of Places and Locations through Research and Evaluation (EXPLoRE). The locations in this report represent 469 cities with populations of at least 500,000 in 2015. Real estate cost and location are only part of the equation with additional emphasis is being placed on labor, training, utilities, and brand perception.